Amicus Therapeutics Adopts Orphan Diseases

Rare and Orphan diseases are the forgotten ones of the medical world. This is due to the fact that as the name shows, they are rare. When a disease is considered to be rare it will rarely receive attention from pharmaceutical companies who are producing cures. This is how a disease becomes an orphan disease. However, there are exceptions to this rule, exceptions such as Amicus Therapeutics. Amicus has been concentrating on developing cures and treatments for rare and orphan diseases grouped as Lysosomal storage disorders. The main ones Amicus is working are Fabry disease, Epidermolysis Bullosa, Pompe disease, and few other rare diseases.

Amicus Therapeutics conducts its scientific research in a deceptively simple way. The chemist is working on two ways to stabilize proteins. The first method is to go the pharmacological chaperone route and the second way is a hybrid method combining a chaperone with enzyme replacement therapy. However, Amicus is in late stage development of a treatment for Fabry disease. What makes this treatment special is that it is done according to a genetic diagnosis. This way, the treatment will not be a “one size fits all” approach to treating individual patients.

Another product that is also in advanced development is SD-101, which will be used to treat those who suffer from Epidermolysis Bullosa (EB), which is a genetic issue that affects the connective tissue ( Amicus Therapeutics does not produce any of its medication in-house. It is all contracted out to third party candidates. The company recently opened another office in San Diego, California.

What makes Amicus Therapeutics an outstanding member of the medical community is their attitude towards their patients. They work closely with individual patients and their care givers, physicians, nurses, and patient organizations to ensure that everybody gets what they need and are reading from the same page. This way, Amicus is able to use feedback to help out in the research and development process. John F. Crowley has been the CEO of Amicus Therapeutics since 2005 (Glassdoor).


Eric Lefkofsky’s Technological Innovation Bringing a Great Relief to Cancer Patients

According to the Norcal News published on 23rd May 2017, Eric Lefkofsky has launched another company, Tempus. This Company will be assembling a genomic database for cancer. Doctors will be using the database to compare DNA of patients so as to know the best therapies for each. This will help cancer patients to live longer and even cure some cancer cases.The Zeal behind the founding of Tempus was trend in medical physicians collecting a lot of medical data, but lack an efficient method for analyzing it for future use. Tempus brings a big technological innovation in the medical field. Its work will even be more possible with the reduced costs of screening genes and storing data.

According to Eric, Tempus Company has advantages in this technological innovation since it has partnered with prominent hospitals with which they can collect huge and reliable data that acts as a sufficient sample size. Also, Tempus has got a spacious and equipped laboratory that will be used for screening and testing the genes. Eric has come up with software that can compare cancer patients DNA profiles. These comparisons will help in finding treatments for patients with the same genetic profiles.Since 2015, Eric Lefkofsky stepped down as the CEO of Groupon so that he can fully concentrate on building Tempus. He then hired Kevin White who is a renowned Geneticist for his work at Genomics and Systems Biology Institute at the University of Chicago. Eric joined Tempus together with his business partner, Brad Key well.

About Eric Lefkofsky

Eric Lefkofsky is the CEO and co-founder of Tempus Company. He also founded the Lightbank fund that invests in disruptive technologies. Eric co-founded Groupon where he was the CEO before he stepped down to concentrate on Tempus in 2015. Other companies that were co-founded by Eric are Uptake Technologies, Mediaocean, Echo Global Logistics and InnerWorkings.Together with his wife, Liz, Eric established ta charitable organization by the name Lefkofsky Family Foundation. Eric holds a Bachelor’s degree from the University of Michigan. He also has a doctorate from the Law School at the University of Michigan.

Devco: The Construction Of The Heldrich Hotel

In the mid-1970s a development company was created to initiate the redevelopment of public and private buildings in the city of New Brunswick. Devco, a company known for its economic revitalization, has handled more than one billion in investments.

Devco was founded by Richard Sellars, a former executive of Johnson&Johnson. The organization’s mission centered around new developments and assisting local establishments like Rutgers University.

Last month was a day of concern, the Press of Atlantic City wrote an article explaining how the Middlesex County Improvement failed to pay the million dollar principal on a loan it received from Casino Reinvestment Development Authority.

The loan was originally made in the year of 2005 and in 2007 it was used to fund the construction of The Heldrich Hotel. The Heldrich is a hotel and conference center located in the New Brunswick area. Devco, also known as the New Brunswick Development Corporation, assisted with the construction and revitalization of the hotel.

After many years of struggle, the hotel finally hit a small economic boost. The 235-room building gained an occupancy of 63.5 percent and gained one of it largest accounts Johnson&Johnson.

The hotel is still struggling with cash, and in some cases have to use its own money to fund capital expenses. Chris Paladino, the attorney handling the arrangement of the loan, stated that CRDA will be paid back, but it’s going to take a few more years before they can successfully pay off their debt.



GLT Integrity Breach Highlighted By Securus

Integrity should be one of the core values for any company. This is important if customers are to be kept satisfied. It is also influences the perceptions that people have on the industry in general. Therefore, if a company cannot uphold integrity in their business, they are not the only party affected; rather, they affect other companies operating in the same industry. That said, I can understand the reason why Securus decided to out GTL on their integrity breach.


GTL has shown a lot of hard-headedness in failing to change their ways, even after being accused, investigated and charged with several wrongdoings in their service delivery processes. This was more than a decade ago. However, even after being given a warning and being penalized, they go on, portraying a high level of impunity, which will not only affect them but the whole industry as a whole, if the trend continues.


When Securus outed GTL, the question on the minds of many was, is Securus in the right position to do so? I say yes. First, they would of course have been affected by the behavior of GTL. If GTL did not change, customers would totally lose trust in the industry. This would lead to loss of business for Securus and other companies providing technological solutions to security and correctional facilities.


No one can say that this was a double-standard incidence on the part of Securus. First, they are the stewards of integrity in the industry. Of course, every company gets its fair share of complaints. However, the way they respond to the complaints is what sets apart companies that uphold integrity and those that do not. Their stewardship can be proved by the recent A+ grading awarded by the BBB rating.

Securus Video Visitation Overview Video from Securus Technologies on Vimeo.

Prominent Financial Firm Giving Help to Veterans Group

Forefront Capital Advisors is putting its financial clout behind a new partnership to help veterans. CEO Brad Reifler announced his company will partner the Easter Seals Dixon Center. The center gives aid to military veterans and their families in finding job, education, and health care opportunities.

Reifler said one of the missions of Forefront Capital is to make a difference in the lives of veterans, and added the partnership makes good business sense. “We believe veterans and their families must have financial stability in order to succeed in their communities after a life of service. Easter Seals Dixon Center offers a unique opportunity for our company, staff and clients to get behind this important cause.”

The partnership between Forefront Capital Advisors and Easter Seals Dixon Center includes a $3 million donation from Forefront. This money will help the center pay for vet programs that focus on job training, health and wellness, caregiver training, and education.

Since 2014, the Easter Seals Dixon Center has helped more than 17,000 veterans and their family members with workforce development programs. They have also helped 5,000 veterans with continuing education. Along with their partnership with Forefront Capital, the center has created more than 1,000 national and corporate partnerships.

Forefront Capital Advisors is a global financial firm that specializes in alternative investment management, merchant banking, and investment banking. It was founded by Brad Reifler, who also serves as the firm’s CEO. He formed Reifler Trading Company during the 1980s, then sold it and established Forefront Capital.  Read more about Brad on CrunchBase, or follow him on Twitter @BradleyR.

Kate Hudson’s New Dresses

Kate Hudson may be mainly known as the leading lady of such movies as the seventies set rock n’ roll drama Almost Famous and her roles in the more recent movies Wish I Was Here and Mother’s Day at She’s not only a famous actress though. Kate is big on having a regular fitness routine. With some guidance from her fitness trainer she does pilates, yoga, dancing and jogging to keep her body looking fly for her movies and for her own health.

Kate has taken her fitness goals to the next level by co-founding the workout gear company Fabletics. Fabletics sells active wear tops, leggings, shorts, sports bras, swim suits and a new line of Fabletics dresses. In an interview she gave to Marie Claire, Kate Hudson discussed the company’s decision to branch out into creating a line of dresses.

The first question she was asked was why Fabletics decided to create a line of dresses. She replied by saying that there are far more active women now who care about being stylish and comfortable.

When asked if she would do the current athleisure trend herself on a date at, she said that she definitely would. Kate insists women nowadays can use pieces of athletic wear in their work, casual, night out or date style.

On whether or not the new line of Fabletics dresses are good to hike in, Kate said they are made from the same material that the active wear is made out of. She stated technically you could, but the dresses are more about being comfortable like work out gear than for being used as hiking or gym wear.

Kate says that many of the Fabletics dresses have built in bras, yet the ones that don’t should work with most usual bras. She also says that spanx are unnecessary for the dresses. Each posted dress is fitted and designed similar to the snug and flattering fit of athletic wear, so the dress itself acts similarly to the control spanx offers.

Marie Claire also questioned her on if the new swim suits from Fabletics are something women can swim in or work out in. She insists that they were built to be used actively on land and water. The likelihood of the swim suit popping off by accident is very small a chance, as they were made sturdily for ladies who don’t want their swim bottoms slipping off when swimming or for their chest to accidentally slip out of their swim suit top.

Kate closed the interview by saying she is looking forward to seeing the future of the athleisure trend. She believes the trend could easily become high fashion.

Sanjay Shah Invests in Health and Development

Sanjay Shah is very successful and has a high network because of his skill n making the right investments. He has worked for plenty of investment banks and has even started his own firm in which he made his own investments. In his spare time, he has used some of his profits earned in order to donate to different charitable causes. His understanding of the markets has made him a very profitable investor. He is also someone who loves to think outside of the box. He does not like to limit himself to the office. He is also interested in finding cures or effective treatments to different disorders.

Among the medical issues that Shah is dealing with is Autism. Autism is a term that is commonly used to describe a group of developmental issues in the brain. This often manifests as difficulties in social interaction. Often times, there tends to be symptoms of autism making their appearance in the second or third age of the young child. Sanjay Shah has experienced the tragedy of learning that his child has that development disorder. Therefore, he is looking for ways to treat it. He is focusing all of his efforts towards funding the research needed in order to find a more effective treatment of autism.

Sanjay Shah’s company, Solo Capital Markets is a financial services company. The company as a whole participates in consultation, making trades and investing in professional sports teams. Under the lead of Shah, Solo Capital Partners has managed to gain a net worth of 15.45 million with assets that total to an even greater amount.

Sanjay Shah is an example of someone who not only takes risks, but makes calculated decisions. While it is true that with great risk can come great rewards, it is the one who thinks everything through who is more likely to come out with greater rewards than the costs associated with it.

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2016 Is Set To Be a Record Year For Hedge Fund M&A Transactions

Madison Street Capital recently released their 4th edition hedge fund industry M&A overview. The report made mention of the 42 hedge fund deals that were either closed or announced in 2015. Keep in mind these are deals from around the world.

The 42 deals was a pretty decent increase from 2014 when the number of hedge fund deals was 32. Additionally, transaction volume for 2015, which is measured by AUM, was just under 30% higher than it was in 2014. Based on the volume of transactions that took place in 2015, and several other factors that are driving deal momentum, it looks like 2016 is going to be a record year for hedge fund M&A transactions.

Here is a brief summary of the report:

Though most hedge fund strategies had a mediocre performance in 2015, hedge fund industry assets are currently at an all time high. Due to hedge funds not performing as expected, many institutional investors started assigning more funds to the alternative asset management sector.

The hope is they will be able to achieve higher returns and match rising liabilities. Smaller hedge fund managers aren’t having great success as attracting new capital has not been easy. Higher operational costs and downward pressure on fees is forcing managers to seek out alternative strategies.

Karl D’Cunha, the Senior Managing Director at Madison Street Capital, was quoted as saying, “The deal environment for the hedge fund industry was strong in 2015 and will be even stronger in 2016.”

About Madison Street Capital

Madison Street Capital is one of the largest international investment banking firms in the world. They are an integrated, full-service advisory company with clients all over the globe. They help hedge fund managers with Portfolio Valuation, Financial Sponsor Coverage, Capital Introduction, Financial Restructuring and M&A Advisory.

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Communities By Kevin Seawright

Kevin Seawright, who LinkedIn lists as the CFO and Vice President of Newark CEDC, has worked with many different communities to ensure that the community is able to have what they need and the people of the community have been able to be exposed to opportunities in the different areas of study as well as careers. Seawright began his career at a young age, but was introduced to finance even younger than the beginning of the career. His parents began submerging him in the world of finances at the age of 12 and this helped to make him one of the top people in the financial community assessment sector. He used this to ensure that he was able complete his education and propel his career.

He currently operates as the CFO for Newark CEDC. This is the company that has created the success for him to live by and the company has worked with the community of Newark. He has been able to provide the community not only with opportunity for improvement, but also with advancement. The people of the community have been able to be provided with help that was created by Kevin Seawright. This is a community that would not have had the opportunity of the Newark CEDC had not stepped in. Seawright was able to help them more than other agencies had been able to do.

Seawright also worked with a company that was based out of Baltimore. This company was one that was run by governmental bodies and was not something that he felt fit with the style he had originally set out to do concerning financial help for communities. There were many things that the government body was not able to do and Seawright was concerned that he was not going to be able to help as many people as he had previously had with his private sector help of communities. This opportunity proved to be something that Seawright needed to move on from.

Before he began the government work, CrunchBase actually shows that he started his career in Philadelphia. At this time, he helped many smaller communities around the city. These communities were made up of lower income families and he worked to help them get opportunities they may not have had otherwise. At this time, he was able to improve the lives of the people that he could help. He worked with many people in the communities and gave them opportunities not only in the way of jobs, money and housing, but also in education. He is a strong supporter of continuing education and is able to provide people with opportunities to better what they are doing through the use of education. This is one of the easiest ways that communities are held by Seawright.

Highland Capital Management Scoops 2015 Award

On November 11th 2015, the Highland Capital Management, L.P, a Dallas-based firm dealing with investment management which together with its associates has about $20 billion assets that are under management, announced that HCM’s Healthcare Fund received an award for the 2015 HFM Hedge Fund Performance. James Dondero, who is the president and co-founder of HCM, was very pleased with the award and he put that the winning was a testament to devotion, deep experience and the expertise of healthcare investment by Michael Gregory.

The HFM Hedge Fund Performance Award is aimed at recognizing fund of funds, hedge funds and ’40 Acts which have done much greater than their peers on grounds of both qualitative and quantitative factors. The judges put into consideration a one, three and five year performance of data in addition to a pedigree of manager and reputation with investors.

Michael Gregory, the MD and Head of Healthcare Equity and Credit at the HCM, is the one who manages the Healthcare Fund of Highland. The Healthcare ranks as the largest investment sector of Highland and has an over $3 billion in managed assets. The firm also has 11 healthcare sector-professionals who have a combined experience of 130 years.

This recap was originally posted at:

Former executive of Goldman Sachs, Terry Jones was recently hired by HCM as the president of the firm’s institutional products business. Jones brings an experience surpassing 25 years in financial services industry.

About James Dondero

Jim acts as the president and co-founder of HCM and currently stays in Dallas, TX. Jim has more than 3 decades of experience in credit and equity markets that are focused mainly on profitable and distressed investing. Jim also chairs Cornerstone Healthcare, Nexbank and CCS Medical. He also serves as board member of MGM Studios and American Banknote.

Jim graduated with the highest honors from University of Virginia and he is also a Certified Management Accountant. Before HCM, Dondero served as an analyst for corporate bond and later as portfolio manager at the American Express. Dondero participates actively in philanthropic activities. He supports initiatives in education, public policy and veteran’s affairs. Follow him on Facebook and Twitter.